Abul Abbas, MD
	Regulation of T-cell responses and signaling
	Email: abul.abbas@ucsf.edu
Selected Publications | Complete Publications

Our research focuses on the regulation of T-cell responses, and the signals that determine the choice between effector and regulatory cells and between lymphocyte activation and tolerance. We exploit a large panel of transgenic and knockout mouse strains to address fundamental questions in three related areas: systemic tolerance and autoimmunity; memory T-cell development; and functions of interleukin-2 (IL-2).

Selected Publications

1. London CA, Lodge MP, and Abbas AK. Functional responses and costimulator dependence of memory CD4+ T lymphocytes. J. Immunol. 2000; 164:265-272.

2. Dahl AM, Klein C, Andres P, London CA, Mulligan RC, and Abbas AK. Retrovirus mediated expression of Bcl-x prolongs survival of CD28- T cells but does not correct defects in proliferation and Th2 differentiation. J. Exp. Med. 2000; 191:2031-38.

3. Howland KC, Ausubel LJ, London CA, and Abbas AK. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J. Immunol., 2000; 164:4465-70.

4. Abbas, AK and Janeway CA. Immunology: improving on nature in the twenty-first century. Cell 2000; 100:129-138.

5. Kane LP, Andres PG, Howland KC, Abbas AK and Weiss A. Akt, acting through the RE/AP element, provides the CD28 costimulatory signal for upregulation of IL-2 but not Th2 cytokines. Nature Immunology 2001; 2:37-44.

6. Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK and Sharpe AH. CTLA-4 regulates induction of anergy in vivo. Immunity 2001; 14:145-155.

8. Refaeli Y, Van Parijs L, Anderson S and Abbas AK. IFN-g is required for activation-induced death of T cells. J. Exp. Med. 2002: 196:999-1005.

Information last updated September 2007