Celine Colnot, Ph.D.
	Skeletal development and repair
	Email: colnotc@orthosurg.ucsf.edu Websites:Colnot lab
Selected Publications | Complete Publications

My research focuses on the cellular and molecular mechanisms that regulate skeletal development and repair. I have been particularly interested in the similarities between the molecular programs regulating bone development and repair. I have studied the origins of osteoblasts and the role of angiogenesis during long bone development, and the role of angiogenesis, cartilage matrix remodeling and osteogenesis during fracture healing. My research analyses several aspects of bone healing using various mouse models, including tibial fractures, cortical defect healing and implant osseointegration, as well as a model of bone marrow transplantation to analyze the contribution of bone marrow to fracture healing. My current research program concentrates mainly on the role of skeletal stem cells in bone regeneration. My projects seek (i) to gain better knowledge of the contributions of various sources of stem cells to cartilage and bone healing and (ii) to analyze in vivo how these stem cells respond to signals in their environment, such as growth and differentiation factors. In addition, I carry on collaborative work on the role of matrix remodeling and matrix metalloproteinases, and the role of angiogenesis and inflammation in bone healing.

Selected Publications

Colnot, C, Thompson, Z, Miclau, T, Werb, Z, and Helms, JA. (2003) Altered fracture repair in the absence of MMP9. Development, 130:4123-4133.

Colnot, C, de la Fuente, L, Huang, S, Hu, D, Lu, C, St- Jacques, B, and Helms, JA. (2005) Indian Hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development, 132(5): 1057-67.

Colnot, C., Romero, D., Huang, S. and Helms, J.A. (2005) Mechanisms of action of demineralized bone matrix in the repair of cortical bone defects. Clinical Orthopedic Related Research, 435:69-78.

Colnot, C., Huang, S. and Helms J.A. (2006) Analyzing the cellular contribution of bone marrow to fracture healing using bone marrow transplantation in mice. Biochemical and Biophysical Research Communications, 350(3):557-61.

Behonick D. J., Xing Z., Lieu S., Buckley J.M., Lotz J. C., Marcucio R. S., Werb Z., Miclau T. and Colnot C. Role of Matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS ONE, in press.

Information last updated September 2007