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My laboratory studies signaling mechanisms that govern cardiovascular
biology with a focus on protease-activated receptors and G protein-coupled
receptors in general. Work directly related to stem cell biology includes a
project to identify all GPCRs expressed by hematpoietic stem cells and to
identify their roles in HSC homing, self-renewal, and commitment to progenitor fate.
Selected Publications
Sambrano, G.R., Huang, W., Faruqi, T., Mahrus, T., Craik, C., and Coughlin, S.R.
(2000) Protease-activated receptor-4 mediates human
platelet activation by cathepsin G J. Biol. Chem. 275: 6819-6823.
Kataoka, H., McKemy, D., Camerer, E., Zheng, Y.-W., Cheng, A., Griffin, C., and Coughlin, S.R. (2003)
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood 102(9):3224-3231.
Camerer, E., Cornelissen, I., Kataoka, H., Duong, D.N., Zheng, Y.-W. and Coughlin, S.R. (2006)
Roles of protease-activated receptors in a mouse model of endotoxemia. Blood 107(10)3912-21.
Regard, J., Kataoka, H., Cano, D., Camerer, E., Yin, L., Zheng,
Y.W., Scanlan, T., Hebrok, M., and Coughlin, S.R. (2007) Probing cell type-specific functions of Gi in vivo
identifies GPCR regulators of insulin secretion. J. Clin. Invest. (In press).
Information last updated September 2007
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