The DenBesten Laboratory has successfully grown dental pulp stem cells
from human primary (decidous) and permanent teeth. We are also able to isolate
pulp stem cells from developing mouse molars. We have used these cells to
direct differentiation of human ameloblasts from precursor cells isolated from
fetal material. I believe this is a unique and promising field of research that
will have a tremendous impact on individuals affected by tooth loss, as well as
providing a general model to enhance our knowledge of organ regeneration.
Selected Publications
Mathias R.S., Amin U, Mathew CHE, DenBesten P (2000) Increased fluoride content in the
femur growth plate and cortical bone of uremic rats. Ped. Neph 14:935-939.
Li W, Gao C, Yan Y, DenBesten PK. (2003) X-linked amelogenesis imperfecta may
result from decreased formation of tyrosine rich amelogenin peptide Arch Oral Biol 48:177-183.
Zhang Y, Li W, Chi HS, Chen J, DenBesten PK (2007) JNK/c-Jun Signaling Pathway Mediates
the Fluoride-induced Down-regulation of MMP-20 in vitro. Matrix Biology.
Information last updated September 2007
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