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Our primary research interest is in adipose tissue derived stem/progenitor cells.
We have systemically studied the method of isolation of these cells from fat tissue and
liposuction aspirates; various methods of isolating cells according to surface markers
(e.g. CD 35, 90, 105, SSEA-1 etc), cell size, cell viability; in vitro differentiating
characteristics, signaling pathways involved in differentiating into neurons and smooth
muscle cells, in vivo differentiation into muscle (striated and smooth), epithelium, blood
vessels; in vivo tracing of injected cells with MRI; microRNA signatures, genetic changes
after different passages, location of the stem progenitor cells in fat, the effect of
implantation of these cells in animal models of neurogenic impotence,
diabetic impotence, stress urinary incontinence, overactive bladder etc.
We plan to apply for FDA approval and clinical trial in the next 2-3 years.
Selected Publications
Ning H, Lin G, Lue TF, Lin CS. Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells.
Differentiation. 2006 Dec;74(9-10):510-8.
Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, Lue TF. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury.
BJU Int. 2004 Oct;94(6):904-9.
Information last updated September 2007
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