Grayson Marshall, D.D.S., M.P.H., Ph.D.
	Structure-mechanical properties relationships of calcified tissues
	Email: gw.marshall@ucsf.edu Website: Marshall Lab
Selected Publications | Complete Publications

We study structure-mechanical property relationships of calcified tissues (bone, cementum, dentin, enamel). The main functions of these biological materials are mechanical, but much work is needed to understand how their unique and versatile properties are derived based on combinations of protein and mineral. We seek insight into biomineralization processes associated with these tissues during development, resulting from disease, or repair and regeneration from clinical treatments. We also focus on natural interfaces between various calcified tissues and artificial interfaces between the tissues and artificial, e.g., dental restorations, implants, bioactive substrates. We use a wide variety of approaches including atomic force microscopy (AFM); and AFM-based nano-indentation) as well as other complimentary methods including wet SEM and x-ray microanalysis, and participate in wide ranging collaborations in the Bay Area. This work helps define alteration in properties and structure with hydration state, mineral level, and variations induced by disease and physiological processes. This information is needed to develop a composite structural model of calcified tissues and can assist in the development of bio-inspired materials and tissue engineering.

Selected Publications

Mankani MH, Kuznetsov SA, Wolfe RM, Marshall GW, Robey PG. In vivo bone formation by human bone marrow stromal cells: reconstruction of the mouse calvarium and mandible. Stem Cells 2006 24:2140-2149.

Foppiano S, Marshall SJ, Saiz E, Tomsia AP, Marshall GW. Functionally graded bioactive coatings: Reproducibility and stability of the coating under cell culture conditions. Acta Biomaterialia 2006 2:133-142.

Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. TGF-{beta} regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005 102:18813-18818.

Ho SP, Sulyanto RM, Marshall SJ, Marshall GW. The cementum-dentin junction also contains glycosaminoglycans and collagen fibrils. J Struct Biol 2005 151:69-78.

Information last updated April 2007