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The Martin lab is interested in understanding the mechanisms that
control the early steps in organogenesis in the vertebrate embryo, and
the subsequent outgrowth and patterning of the developing organs. We are
particularly interested in the roles played by members of the Fibroblast
Growth Factor (FGF) family of signaling molecules and their antagonists
in these processes. For the most part we use genetic analysis in mice to
uncover the functions of these molecules in the developing embryo.
Selected Publications
Shim, K., Minowada, G. Coling, D. E., and Martin, G. R. (2005).
Sprouty2, a mouse deafness gene, regulates cell fate decisions in the
auditory sensory epithelium by antagonizing FGF signaling. Dev. Cell 8,
553-564.
Grieshammer, U., Cebrián, C., Ilagan, R., Meyers, E. N., Herzlinger, D.
and Martin, G. R. (2005). FGF8 is required for cell survival at distinct
stages of nephrogenesis and for regulation of gene expression in nascent
nephrons. Development 132, 3847-3857.
Klein, O.D., Minowada, G., Peterkova, R., Kangas, A., Yu, B.D., Lesot,
H., Peterka, M., Jernvall, J. and Martin, G. R. (2006). Sprouty genes
control diastema tooth development via bidirectional antagonism of
epithelial-mesenchymal FGF signaling. Dev. Cell 11, 181-190.
Information last updated April 2007
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