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Cardiovascular
The use of signaling molecules, transcription factors, microRNAs and cell cycle regulators to impact proliferation and differentiation of embryonic stem and progenitor cells into the various lineages necessary for cardiac repair is currently being investigated. Attempts to introduce such cells into the damaged heart in rodent and swine models and to seed cells on biodegradable scaffolds for tissue replacement is ongoing.
The program is buttressed by world experts in basic aspects of cardiac differentiation into myocytes, valves and conduction cells as well as leaders in the field of vascular developmentifferentiation. Such investigators span many departments and include but are not limited to members of the Division of Adult Cardiology within the Department of Internal Medicine, the Cardiovascular Research Institute and the Gladstone Institute of Cardiovascular Disease. Together, we arguably have the richest concentration of basic science research in cardiovascular biology. In addition, there is a vigorous interest in development of animal models for cardiac disease across many departments, including the Division of Cardiology within the Department of Internal Medicine, the Department of Surgery and the Department of Radiology. Finally, within the Divisions of Adult Cardiology and Pediatric Cardiology there is excitement and expertise to begin to design patient-based clinical trials when appropriate. Both divisions care for large numbers of patients and are recognized as leaders in the area of cardiovascular medicine.
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